Kelas : 3EB24
NPM: 29214956
Review Article 7
State of the art
on oocyte cryopreservation in female cancer patients: A critical review of the
literature
Highlights
- •Physicians should discuss fertility preservation
with women facing gonadotoxic therapies.
- •Data about the efficacy of oocyte
cryopreservation in cancer patients are lacking.
- •Results in non-oncologic patients can be
reasonably translated in the cancer setting
Abstract
During the last decades,
important advances in therapeutic options have led to increased survival rates
in cancer patients; however, cancer treatments are associated with several
potential adverse effects including infertility in those diagnosed during their
reproductive years. A proper discussion about fertility preservation options
before the use of therapies with potential gonadotoxicity (i.e. oncofertility
counseling) is standard of care and should be offered to all patients of
childbearing age. Temporary ovarian suppression with LH-RH analogs, oocyte and
embryo cryopreservation are standard strategies for fertility preservation in
female cancer patients. Oocyte cryopreservation should be preferred to embryo
cryopreservation when this latter is prohibited by law, avoided for ethical or
religious issues and in single women refusing sperm donation. Despite the
increasing use of this strategy, data are still lacking about the efficacy and
safety of the procedure in female cancer patients, with most of the evidence on
this regard deriving from infertile non-oncologic women. This article aims at
critically review the available evidence about the success of oocyte
cryopreservation in female cancer patients with the final goal to further
improve the oncofertility counseling of these women.
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